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which face mask design is associated with improved drug delivery to the lungs?

by:SWIFT     2020-03-26
The peer-
The review research article Selected to teach the scientific methods of this problem is: Keith W. Harris, M. D. and Gerald C.
Doctor of MedicineD.
Facial and eye deposition by atomization inhalation of budined-
The effect of mask design.
Chest, February 2008;
Volumetro: Months, page 482nd488.
The authors are from the Department of lung, intensive care and sleep medicine, the department of medicine at the State University of New York at Stony Brook. [
Slightly] Illustrations
The background or introduction to the research project explains the interest in the topic and why it is important.
The authors note that using mask atomization therapy deposits droplets in the lungs, as well as in the face and eyes, due to the natural ofaerosol that escapes from the edge of the mask.
According to the atomization effect of the drug, entering the eye may lead to pupil expansion and glaucoma, the authors noted.
To study the aerosol in the laboratory rather than by the bed, a model of the face and face mask that is ventilated like a patient is required.
The authors describe a customized child facial model that provides oral breathing patterns by apiston pumps connected to the back of the mouth.
This mannequin system is used in the study of various combinations of face masks and nebulizers.
The question raised by the researchers is: does facial massage design affect the behavior of inhaled drugs?
Note: possible answers to questions raised in research projects;
In this study, \"Yes\" and \"no\", or it may be a digital result.
The preconceived answer to this question by researchers is called hypothesis.
Although the researchers did not indicate their hypothesis, experienced people may propose that, yes, mask design affects the behavior of inhaled drugs.
The method of the research project describes the steps of the research design, setup, and answer questions.
The author used
Vitrodesign, meaning the study was conducted in a laboratory without human subjects.
Research with humans will be calledvivo design.
Since the study does not involve human subjects, the authors do not need an institutional review committee (IRB)approval. The set-
In their lab, the child\'s simulated face is used instead of the mouth.
The various nebulizers connected to the compressor will produce aerosol on the mask.
The piston pump provides a suction and breathing mode that simulates the mouth, with pediatric breathing mode of 50 ml tidal volume and 25 breaths per minute.
Aerosol drug particles through the annequin mouth are measured by deposition on the suction filter attached to the back of the mouth.
The aerosol deposition on the eyes was determined by measuring the amount of drugs deposited on the filter, which replaced the eyes of the human model.
The aerosol deposition on the face was determined by measuring the amount of drugs deposited on the filter on the surface of the human model.
The drug is produced by the author, budesonidesusion (
Pumic Lingshu; AstraZeneca LP;
Horse)
, Waste when the standard dose is 0. 5 mg in 2.
Normal Saline 0 ml.
Each different combination of face masks and nebulizers has been tested in triplicate and cumulative aerosol deposition has been measured on the suction mass filter after the mouth, the filter on the eyes and the filter on the face
Combining three processes to represent a single data point, the authors obtain two data points for each different combination of shielding and nebulizer.
The authors directly studied the \"pre-loading\" masks connected to the nebulizer via a 90 degree elbow, as well as the \"bottom loading\" masks with a lower connection to the nebulizer.
Statistical analysis is based on the equal number of cloth Ned loaded into the nebulizer to be delivered to the human model (\'patient\")
Every experiment.
The authors report the results of the percentage of charge in the nebulizer and compare the \"front-
\"Loaded\" and \"loaded at the bottom\" sets-ups.
The result part compiles the data into an answer.
Author\'s comments on the data in the \"pre-load\" and \"under-load\" collections
Ups is displayed on a table with a large amount of inhaled substances, eye deposits and facial deposits.
Mask design is the main factor that affects the delivery of cloth Ned spray through the mouth, eyes and face of the human body model.
Compared to the \"bottom mount\" mask, the \"front mount\" mask delivers more medication through the mouth, while less for the eyes and face.
Discussion/reflection/future research begins with a summary discussion of the study.
In this research project, the authors note that particle inertia along the edge of the mask explains the deposition of the eyes and face. A tight-
Accessory masks can actually make the aerosol faster than loose --fitting mask.
High-speed air is more likely to deposit in the eyes and face.
This reflection is a comparison with similar research projects and a criticism of the author\'s own research projects.
The authors point out that nomannequin can replicate all possible faces, and can actually replicate any living face as well.
The authors explained that the nebula was selected to improve efficiency and constant flow.
Future studies describe modifications to the project or to new projects that contribute to the topic of the study.
The authors point out that it is a new study to study the mask as a device rather than a simple connector.
The conclusion is the final summary of the research project.
This research project shows that the \"front loading\" mask has less impact on the eyes and face than the \"bottom loading\" mask.
Therefore, the problem was properly solved in this research project.
The assumptions put forward are correct.
Thanks to those who helped research projects through time/effort and financial support.
Thanks to RogerGrimson, Ph. D.
For statistical analysis and Lorin MoraS.
Mr. andakar ShahD.
Technical assistance.
All participating authors of research project articles list conflicts of interest.
Conflicts include members of the advisory board, ownership of shares, and receipt of services, gratuities or gifts from companies related to research projects. Dr.
Harris had no conflict of interest. Dr.
Smalldone, paid consultant listedas of PARI Respiratory Equipment Co. , Ltd. , has consulted AstraZeneca and has obtained a license patent for PARI mask design.
The bibliography section includes references to support the study contained in the manuscript through the reference number.
There are 17 references to this research project.
Herbert Patrick, MD Herbert PatrickD. , M. S. E. E.
He is an associate professor of medicine and director of intensive care services at Dreiser University School of Medicine.
Herbert will probably reach him.
Patrick @ drexelmededu.
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